Source
Department of Obstetrics & Gynaecology, Sahlgrenska Academy, University of Göteborg, SE-413 45 Göteborg, Sweden. bjorn.strander@oc.gu.se
Abstract
BACKGROUND:
Women once treated for high grade cervical dysplasia have a high long term risk for developing new dysplasia or cancer.
OBJECTIVES:
To investigate if human papilloma virus (HPV)-negativity after treatment of cervical dysplasia reduces the need for frequent long term follow up.
DESIGN:
Case/control study based on archival smears.
METHODS:
Women with cervical intraepithelial neoplasi (CIN)2-3, treated for dysplasia and with recurrence of CIN2+ more than 2 years after treatment were compared with controls without recurrence, matched for age and date of treatment. High risk-HPV-DNA were analysed with PCR from two archival smears per woman. Mean follow up time was 14.6 years.
RESULTS:
24% (45/189) of cases and 11% (43/378) of controls were HPV-positive in any of two smears. Odds ratio (OR)=2.5 (1.6-3.8).
CONCLUSION:
HPV-status 6-12 months after treatment of high grade dysplasia is of limited value for the design of long term follow up.