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Curr Opin Pharmacol. 2007 Aug;7(4):360-6. Epub 2007 Jul 5.

Gamma-glutamyltransferase, redox regulation and cancer drug resistance.

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  • 1Dipartimento di Patologia Sperimentale, Universit√† di Pisa, Scuola MedicaVia Roma 55, 56126 Pisa, Italy.

Abstract

Gamma-glutamyltransferase, a key enzyme of GSH metabolism, can modulate crucial redox-sensitive functions, such as antioxidant/antitoxic defences and cellular proliferative/apoptotic balance, with potential implications in tumour progression and drug resistance. Recent studies have elucidated the mechanisms of GGT involvement in various pathological processes suggesting its potential role as therapeutic target and diagnostic/prognostic marker.

PMID:
17613273
[PubMed - indexed for MEDLINE]
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