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Chronobiol Int. 2007;24(3):407-11.

Phase response curve to melatonin in a putatively diurnal rodent, Octodon degus.

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  • 1Division of Sleep Medicine & Surgery, Department of Otolaryngology, New York University School of Medicine, New York, USA.


The degu (Octodon degus) is a diurnal rodent, although phase inversions to nocturnal behavior have been reported under specific laboratory conditions. The reliability of this animal as a diurnal model of sleep therefore requires further characterization of intrinsic circadian pacemaker properties. A phase response curve to light has been reported in the degu, and is consistent with other diurnal animals. This study reports a phase response curve to melatonin in the degu, which is distinct in orientation from the light curve.

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