Arch Microbiol. 2007 Nov;188(5):541-6. Epub 2007 Jul 5.

The Streptomyces coelicolor dnaK operon contains a second promoter driving the expression of the negative regulator hspR at physiological temperature.

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Dipartimento di Biologia Cellulare e dello Sviluppo, Viale delle Scienze-Parco d'Orleans II, 90128, Palermo, Italy.

Abstract

HspR (heat shock protein regulator) acts as a negative regulator of different genes in many bacteria. In Streptomyces coelicolor hspR gene is part and the transcriptional repressor of the dnaK operon which encodes the DnaK, GrpE, DnaJ chaperone machines and HspR itself. Our experiments led us to the discovery of a second promoter, internal to dnaK operon, located upstream hspR gene. Transcription from this promoter was detected at 30 degrees C indicating that hspR could play a key physiological role.

PMID:: 17611737; [PubMed - indexed for MEDLINE]

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The Streptomyces coelicolor dnaK operon contains a second promoter driving the expression of the negative regulator hspR at physiological temperature.

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