Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Neurol Sci. 2008 Feb 15;265(1-2):73-7. Epub 2007 Jul 3.

Neural stem/precursor cells for the treatment of ischemic stroke.

Author information

  • 1Department of Neurology, University Hospital Zurich (USZ), Frauenklinikstr, 26, CH-8091 Zurich, Switzerland.

Abstract

In ischemic stroke, the third most frequent cause of mortality in industrialized countries, therapeutic options have until now been limited to the first hours after disease onset. Cell transplantation has emerged in various neurological disorders, including experimental stroke, as a successful recovery-promoting approach also in the post-acute stroke phase. However, before envisaging any translation into humans of such promising cell-based approaches we still need to clarify: (i) the ideal cell source for transplantation, (ii) the most appropriate route of cell administration, and, last but not least, (iii) the best approach to achieve an appropriate and functional integration of transplanted cells into the host tissue. Here we discuss, with special emphasis on neural stem/precursor cells, potential mechanisms that may be involved in the action of cell-based therapies in stroke.

PMID:
17610905
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk