Abstract
Seven new aroyl uridine derivatives (kipukasins A-G; 1-7) were isolated from solid-substrate fermentation cultures of two different Hawaiian isolates of Aspergillus versicolor. The structures of compounds 1-7 were determined by analysis of NMR and MS data. The nucleoside portion of lead compound 1 was assigned as uracil-1-beta-D-ribofuranoside by spectral comparison with an authentic standard. The bioactivity of the original A. versicolor extracts was accounted for mainly by the presence of the known metabolite sterigmatocystin, but kipukasins A and B showed modest activity in assays against Gram-positive bacteria.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Aspergillus / chemistry*
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Gram-Positive Bacteria / drug effects
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Hawaii
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Microbial Sensitivity Tests
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Mycotoxins / chemistry
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Mycotoxins / isolation & purification*
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Mycotoxins / pharmacology
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Nucleosides / chemistry
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Nucleosides / isolation & purification*
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Nucleosides / pharmacology
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Sterigmatocystin / isolation & purification
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Sterigmatocystin / pharmacology
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Uridine / analogs & derivatives*
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Uridine / chemistry
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Uridine / isolation & purification
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Uridine / pharmacology
Substances
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Anti-Bacterial Agents
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Mycotoxins
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Nucleosides
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kipukasin A
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kipukasin B
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Sterigmatocystin
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Uridine