Liver transplantation has revolutionized the management of acute or fulminant liver failure. Overall success rates of liver transplantation are satisfactory, although not as high as for elective transplantation. Although the bulk of liver transplants use standard whole grafts, interesting data are emerging on auxiliary liver grafts and donations from living donors. Liver transplantation is an integral part of management protocols complementing the sophisticated critical care protocols that have contributed significantly to the overall improved outcomes seen in acute liver failure. The potential for liver support devices to have an impact on the need for liver transplantation and outcomes after transplantation remains exciting.