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Cell. 2007 Jun 29;129(7):1251-2.

Making COPII coats.

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  • Department of Cell Biology, Harvard Medical School, Boston, MA 02115-5701, USA. kirchhausen@crystal.harvard.edu


Newly synthesized proteins en route to the Golgi apparatus are exported from the endoplasmic reticulum by COPII coated vesicles. Fath et al. (2007) now reveal the structure of a large portion of the yeast Sec13/31 complex, which comprises the coat framework of COPII-coated vesicles. Their findings suggest a mechanism by which the COPII cage assembles and accommodates cargo of different sizes.

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