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1: Nano Lett. 2007 Aug;7(8):2300-6. Epub 2007 Jun 29.Click here to read Links

Identity profiling of cell surface markers by multiplex gold nanorod probes.

Yu C, Nakshatri H, Irudayaraj J.

Department of Agricultural and Biological Engineering and Bindley Biosciences Center, Purdue University, 225 South University Drive, West Lafayette, Indiana 47906, USA.

Gold nanorod molecular probes (GNrMPs) were designed and fabricated for multiplex identification of cell surface markers in HBECs. Cells were probed directly using dark field microscopy integrated with a spectral imager for simultaneous detection of up to three surface markers. The immunophenotype composition of these cell lines indicative of their metastasis potential was assessed using the GNrMPs. The technique has the potential to become an important tool for diagnosis and prognosis of breast and other cancers.

PMID: 17602538 [PubMed - indexed for MEDLINE]

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