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Perit Dial Int. 2007 Jul-Aug;27(4):424-31.

The effects of irbesartan and spironolactone in prevention of peritoneal fibrosis in rats.

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  • 1Department of Nephrology, Dokuz Eyl├╝l University Medical School, Izmir, Turkey. uzmanersoy@yahoo.com

Abstract

BACKGROUND:

Bacterial peritonitis episodes may disturb the functional and histological integrity of the peritoneum in peritoneal dialysis patients. The renin-angiotensin-aldosterone system may have fibrotic effects on the peritoneum.

OBJECTIVE:

To study the effects of an angiotensin II receptor antagonist (irbesartan) and an aldosterone antagonist (spironolactone) in the prevention of peritoneal fibrosis in a rat model of bacterial peritonitis.

METHODS:

40 Wistar rats were randomized into 5 groups: bacteria (B), bacteria-irbesartan (BI), bacteria-spironolactone (BS), bacteria-irbesartan-spironolactone (BIS), and control (C) groups. The C group received only dextran beads (Cytodex; Sigma Chemicals, St Louis, Missouri, USA); the others were given bacteria and dextran beads intraperitoneally. Irbesartan and/or spironolactone were given to 3 groups: BI, BS, and BIS. On the eighth day, the rats were sacrificed, peritoneal adhesion was quantified, and peritoneal tissue sections were evaluated histologically.

RESULTS:

The peritoneal total adhesion score was significantly higher in the B group than in the BI, BIS, and C groups (p < 0.01). Mean peritoneal thickness, mean inflammation score, and mean fibrosis score were significantly higher in the B group in comparison to the C group (p < 0.05). Mean peritoneal thickness of all treatment groups was significantly lower than the B group (p < 0.05). Serum transforming growth factor beta-1 level was significantly higher in the B group than in the BI, BS, and C groups (p < 0.05).

CONCLUSION:

Irbesartan and spironolactone seem to decrease the extent of peritoneal injury caused by bacterial peritonitis.

PMID:
17602151
[PubMed - indexed for MEDLINE]
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