J Intern Med. 2007 Jul;262(1):44-58.

Mucosal immune responses in the genital tract of HIV-1-exposed uninfected women.

Source

Center for Molecular Medicine, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.

Abstract

The development of HIV-1 vaccines and microbicides remains hindered by our limited understanding of correlates of immune protection to infection. Evidence indicating that resistance to HIV-1 infection is indeed possible comes from HIV-1-exposed yet uninfected individuals, including cohorts of commercial sex workers and discordant couples. Despite their uninfected status some of these individuals have mucosal and systemic HIV-1-specific humoral and cellular immune responses in addition to their innate immune response. The combined contribution of innate and adaptive immunity as well as genetic factors is most likely of great importance for this protection against infection. Here we review data on the antibody responses and secreted immune molecules of the innate immune system in the female genital tract with emphasis on individuals who seem to resist HIV-1-infection despite repeated exposure to the virus.

PMID:: 17598814; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Supplemental Content

Save items

Related citations in PubMed

Elevated elafin/trappin-2 in the female genital tract is associated with protection against HIV acquisition. [AIDS. 2009]
Elevated elafin/trappin-2 in the female genital tract is associated with protection against HIV acquisition.
Iqbal SM, Ball TB, Levinson P, Maranan L, Jaoko W, Wachihi C, Pak BJ, Podust VN, Broliden K, Hirbod T, et al. AIDS. 2009 Aug 24; 23(13):1669-77.
Review Humoral immune responses to the human immunodeficiency virus type-1 (HIV-1) in the genital tract compared to other mucosal sites. [J Reprod Immunol. 2006]
Review Humoral immune responses to the human immunodeficiency virus type-1 (HIV-1) in the genital tract compared to other mucosal sites.
Mestecky J. J Reprod Immunol. 2006 Dec; 72(1-2):1-17.
Absence of specific mucosal antibody responses in HIV-exposed uninfected sex workers from the Gambia. [AIDS. 2000]
Absence of specific mucosal antibody responses in HIV-exposed uninfected sex workers from the Gambia.
Dorrell L, Hessell AJ, Wang M, Whittle H, Sabally S, Rowland-Jones S, Burton DR, Parren PW. AIDS. 2000 Jun 16; 14(9):1117-22.
Functional HIV-1 specific IgA antibodies in HIV-1 exposed, persistently IgG seronegative female sex workers. [Immunol Lett. 2001]
Functional HIV-1 specific IgA antibodies in HIV-1 exposed, persistently IgG seronegative female sex workers.
Broliden K, Hinkula J, Devito C, Kiama P, Kimani J, Trabbatoni D, Bwayo JJ, Clerici M, Plummer F, Kaul R. Immunol Lett. 2001 Nov 1; 79(1-2):29-36.
Review Genital and oral mucosal immune response against HIV-1 in exposed uninfected individuals. [Crit Rev Immunol. 2009]
Review Genital and oral mucosal immune response against HIV-1 in exposed uninfected individuals.
Hasselrot K. Crit Rev Immunol. 2009; 29(5):369-77.

See reviews... See all...

Cited by 10 PubMed Central articles

Antibody-Mediated Fcγ Receptor-Based Mechanisms of HIV Inhibition: Recent Findings and New Vaccination Strategies. [Viruses. 2009]
Antibody-Mediated Fcγ Receptor-Based Mechanisms of HIV Inhibition: Recent Findings and New Vaccination Strategies.
Holl V, Peressin M, Moog C. Viruses. 2009 Dec; 1(3):1265-94. Epub 2009 Dec 15.
Differential innate immune responses to low or high dose oral SIV challenge in Rhesus macaques. [Curr HIV Res. 2011]
Differential innate immune responses to low or high dose oral SIV challenge in Rhesus macaques.
Durudas A, Chen HL, Gasper MA, Sundaravaradan V, Milush JM, Silvestri G, Johnson W, Giavedoni LD, Sodora DL. Curr HIV Res. 2011 Jul; 9(5):276-88.
Review Evidence for the innate immune response as a correlate of protection in human immunodeficiency virus (HIV)-1 highly exposed seronegative subjects (HESN). [Clin Exp Immunol. 2011]
Review Evidence for the innate immune response as a correlate of protection in human immunodeficiency virus (HIV)-1 highly exposed seronegative subjects (HESN).
Tomescu C, Abdulhaqq S, Montaner LJ. Clin Exp Immunol. 2011 May; 164(2):158-69. Epub 2011 Mar 17.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Mucosal immune responses in the genital tract of HIV-1-exposed uninfected women.
Mucosal immune responses in the genital tract of HIV-1-exposed uninfected women.
J Intern Med. 2007 Jul ;262(1):44-58.

PubMed
Headache in German children and adolescents: a population-based epidemiological ...
Headache in German children and adolescents: a population-based epidemiological study.
Cephalalgia. 2007 Jun ;27(6):519-27.

PubMed
C-reactive protein and low albumin are predictors of morbidity and cardiovascula...
C-reactive protein and low albumin are predictors of morbidity and cardiovascular events in chronic kidney disease (CKD) 3-5 patients.
Clin Nephrol. 2007 Jun ;67(6):352-7.

PubMed
Principles and implementation of diffusion-weighted and diffusion tensor imaging...
Principles and implementation of diffusion-weighted and diffusion tensor imaging.
Pediatr Radiol. 2007 Aug ;37(8):739-48. Epub 2007 Jun 28 .

PubMed
Prescribing of hormone therapy for menopause, tibolone, and bisphosphonates in w...
Prescribing of hormone therapy for menopause, tibolone, and bisphosphonates in women in the UK between 1991 and 2005.
Eur J Clin Pharmacol. 2007 Sep ;63(9):843-9. Epub 2007 Jun 28 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: