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Bioinformation. 2006 Apr 11;1(4):127-9.

Ligation site in proteins recognized in silico.

Author information

  • 1Department of Bioinformatics and Telemedicine, Collegium Medicum - Jagiellonian University, Kopernika 17, 31-501 Krakow, Poland.

Abstract

Recognition of a ligation site in a protein molecule is important for identifying its biological activity. The model for in silico recognition of ligation sites in proteins is presented. The idealized hydrophobic core stabilizing protein structure is represented by a three-dimensional Gaussian function. The experimentally observed distribution of hydrophobicity compared with the theoretical distribution reveals differences. The area of high differences indicates the ligation site.

AVAILABILITY:

http://bioinformatics.cm-uj.krakow.pl/activesite.

PMID:
17597871
[PubMed]
PMCID:
PMC1891674
Free PMC Article
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