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Nat Clin Pract Oncol. 2007 Jul;4(7):415-23.

Risk factors and hormone-receptor status: epidemiology, risk-prediction models and treatment implications for breast cancer.

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  • 1Channing Laboratory, Brigham and Women's Hospital, Boston, MA 02115, USA.


It is increasingly being recognized that breast cancer does not represent a single homogeneous disease; instead, the hormone-receptor status defines important clinical and etiologic differences. We review the epidemiologic data on differences in risk-factor associations by hormone-receptor status and highlight major trends in the literature. We discuss the development and evaluation of breast cancer risk models, with a focus on the Rosner and Colditz model, which can separately estimate the risk of hormone-receptor-positive and hormone-receptor-negative breast cancers. We also discuss the clinical implications of accounting for hormone-receptor status in breast cancer risk-prediction models.

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