Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11394-9. Epub 2007 Jun 25.

Pathological role of osteoclast costimulation in arthritis-induced bone loss.

Ochi S, Shinohara M, Sato K, Gober HJ, Koga T, Kodama T, Takai T, Miyasaka N, Takayanagi H.

Source

Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan.

Abstract

Abnormal T cell immune responses induce aberrant expression of inflammatory cytokines such as TNF-alpha, leading to osteoclastmediated bone erosion and osteoporosis in autoimmune arthritis. However, the mechanism underlying enhanced osteoclastogenesis in arthritis is not completely understood. Here we show that TNF-alpha contributes to inflammatory bone loss by enhancing the osteoclastogenic potential of osteoclast precursor cells through inducing paired Ig-like receptor-A (PIR-A), a costimulatory receptor for receptor activator of NF-kappaB (RANK). In fact, bone erosion and osteoporosis, but not inflammation, caused by aberrant TNF-alpha expression were ameliorated in mice deficient in Fc receptor common gamma subunit or beta(2)-microglobulin, in which the expression of PIR-As and PIR-A ligands is impaired, respectively. These results establish the pathological role of costimulatory receptors for RANK in bone loss in arthritis and may provide a molecular basis for the future therapy of inflammatory diseases.

PMID:: 17592115; [PubMed - indexed for MEDLINE]
PMCID:: PMC2040909

Free PMC Article

Images from this publication.See all images (6) Free text

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

See the articles identified as outstanding by F1000's Faculty of 10,000 renowned researchers and clinicians. - F1000

Medical

Molecular Biology Databases

KOMP Repository

Miscellaneous

Mouse Genome Informatics (MGI)

Supplemental Content

Save items

Related citations in PubMed

Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development. [J Immunol. 2008]
Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.
Mori Y, Tsuji S, Inui M, Sakamoto Y, Endo S, Ito Y, Fujimura S, Koga T, Nakamura A, Takayanagi H, et al. J Immunol. 2008 Oct 1; 181(7):4742-51.
Suppressors of cytokine signaling-1 and -3 regulate osteoclastogenesis in the presence of inflammatory cytokines. [J Immunol. 2005]
Suppressors of cytokine signaling-1 and -3 regulate osteoclastogenesis in the presence of inflammatory cytokines.
Ohishi M, Matsumura Y, Aki D, Mashima R, Taniguchi K, Kobayashi T, Kukita T, Iwamoto Y, Yoshimura A. J Immunol. 2005 Mar 1; 174(5):3024-31.
Regulatory T cells protect from local and systemic bone destruction in arthritis. [J Immunol. 2010]
Regulatory T cells protect from local and systemic bone destruction in arthritis.
Zaiss MM, Frey B, Hess A, Zwerina J, Luther J, Nimmerjahn F, Engelke K, Kollias G, Hünig T, Schett G, et al. J Immunol. 2010 Jun 15; 184(12):7238-46. Epub 2010 May 17.
Review TNF-alpha and pathologic bone resorption. [Keio J Med. 2005]
Review TNF-alpha and pathologic bone resorption.
Boyce BF, Li P, Yao Z, Zhang Q, Badell IR, Schwarz EM, O'Keefe RJ, Xing L. Keio J Med. 2005 Sep; 54(3):127-31.
Review Tumor necrosis factor-alpha: molecular and cellular mechanisms in skeletal pathology. [Gene. 2003]
Review Tumor necrosis factor-alpha: molecular and cellular mechanisms in skeletal pathology.
Nanes MS. Gene. 2003 Dec 4; 321:1-15.

See reviews... See all...

Cited by 13 PubMed Central articles

Biomarkers for severity of spinal cord injury in the cerebrospinal fluid of rats. [PLoS One. 2011]
Biomarkers for severity of spinal cord injury in the cerebrospinal fluid of rats.
Lubieniecka JM, Streijger F, Lee JH, Stoynov N, Liu J, Mottus R, Pfeifer T, Kwon BK, Coorssen JR, Foster LJ, et al. PLoS One. 2011 Apr 29; 6(4):e19247. Epub 2011 Apr 29.
Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis. [J Exp Med. 2010]
Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis.
Joyce-Shaikh B, Bigler ME, Chao CC, Murphy EE, Blumenschein WM, Adamopoulos IE, Heyworth PG, Antonenko S, Bowman EP, McClanahan TK, et al. J Exp Med. 2010 Mar 15; 207(3):579-89. Epub 2010 Mar 8.
Adenosine A(1) receptors regulate bone resorption in mice: adenosine A(1) receptor blockade or deletion increases bone density and prevents ovariectomy-induced bone loss in adenosine A(1) receptor-knockout mice. [Arthritis Rheum. 2010]
Adenosine A(1) receptors regulate bone resorption in mice: adenosine A(1) receptor blockade or deletion increases bone density and prevents ovariectomy-induced bone loss in adenosine A(1) receptor-knockout mice.
Kara FM, Doty SB, Boskey A, Goldring S, Zaidi M, Fredholm BB, Cronstein BN. Arthritis Rheum. 2010 Feb; 62(2):534-41.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Pathological role of osteoclast costimulation in arthritis-induced bone loss.
Pathological role of osteoclast costimulation in arthritis-induced bone loss.
Proc Natl Acad Sci U S A. 2007 Jul 3 ;104(27):11394-9. Epub 2007 Jun 25 .

PubMed
Use of antidepressants and rates of hip bone loss in older women: the study of o...
Use of antidepressants and rates of hip bone loss in older women: the study of osteoporotic fractures.
Arch Intern Med. 2007 Jun 25 ;167(12):1240-5.

PubMed
Nitinol stent implantation versus percutaneous transluminal angioplasty in super...
Nitinol stent implantation versus percutaneous transluminal angioplasty in superficial femoral artery lesions up to 10 cm in length: the femoral artery stenting trial (FAST).
Circulation. 2007 Jul 17 ;116(3):285-92. Epub 2007 Jun 25 .

PubMed
Transitivity in Arabidopsis can be primed, requires the redundant action of the ...
Transitivity in Arabidopsis can be primed, requires the redundant action of the antiviral Dicer-like 4 and Dicer-like 2, and is compromised by viral-encoded suppressor proteins.
RNA. 2007 Aug ;13(8):1268-78. Epub 2007 Jun 25 .

PubMed
Isolation of microRNA targets by miRNP immunopurification.
Isolation of microRNA targets by miRNP immunopurification.
RNA. 2007 Aug ;13(8):1198-204. Epub 2007 Jun 25 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: