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Gastrointest Endosc. 2007 Jul;66(1):37-43.

Infrared fluorescence endoscopy for the diagnosis of superficial gastric tumors.

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  • 1Department of Digestive and Cardiovascular Medicine, University of Tokushima Graduate School, Tokushima City, Japan.

Abstract

BACKGROUND:

Indocyanine green (ICG) is a fluorescent marker that is excited by rays at a wavelength of 768 nm to emit fluorescence at a wavelength of 807 nm in the infrared (IR) range. We developed an IR fluorescence endoscope (IRFE) to observe superficial gastric tumors and assessed its clinical usefulness.

OBJECTIVE:

To evaluate the clinical usefulness of an IRFE for the assessment of superficial gastric tumors.

DESIGN:

An observational study.

SETTING:

University hospital.

INTERVENTIONS:

Newly developed IRFE.

PATIENTS:

Thirty patients with gastric tumors were enrolled in this study, and their lesions were subjected to endoscopic submucosal dissection (ESD), or laparoscopic gastrectomy after observation with the IRFE.

METHODS:

Gastric lesions were subjected to conventional observation, followed by IR fluorescence observation before and after intravenous ICG (0.01 mg/kg) injection.

MAIN OUTCOME MEASUREMENTS:

The relationship between the positive fluorescence and invasivity of each tumor.

RESULTS:

Fluorescence was positive in 8 of 10 gastric cancers with submucosal invasion (80%) and 1 of 20 adenomas or intramucosal gastric cancers (5%); the difference was statistically significant (P<.01).

CONCLUSION:

IRFE is a useful diagnostic tool for estimating the invasivity of gastric tumors.

PMID:
17591472
[PubMed - indexed for MEDLINE]
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