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    Anaesth Intensive Care. 2007 Jun;35(3):428-32.

    The use of activated protein C in severe Plasmodium falciparum malaria.

    Rankin LG, Austin DL.

    Source

    Intensive Care Unit, Whangarei Base Hospital, Whangarei, New Zealand.

    Abstract

    A 56-year-old man presented to a peripheral hospital in New Zealand with severe Plasmodium falciparum malaria with cerebral involvement and subsequently developed multi-system organ failure. Activated protein C was used in an attempt to stop the cascade of events into multi-organ failure. Severe infection with P. falciparum is life-threatening and appears to activate a hypercoagulable state similar to that of severe sepsis. Activated protein C is currently used in the treatment of severe sepsis and may provide a new adjuvant therapy for severe P. falciparum malaria.

    PMID:
    17591142
    [PubMed - indexed for MEDLINE]

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