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Int J Gynaecol Obstet. 2007 Aug;98(2):88-92. Epub 2007 Jun 25.

Antepartum percutaneous renal biopsy.

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  • 1Department of Obstetrics and Gynecology, University Hospital, University of Lund, 221-85 Lund, Sweden.



To assess the value and adverse effects of an ultrasound-guided renal biopsy technique in women with normal and pathologic pregnancies.


Biopsy samples were taken from 36 women with hypertensive disease (28 with pre-eclampsia) and 18 healthy pregnant women using a thin needle and an ultrasound-guided biopsy device.


Glomerular endotheliosis, a structural change typical of pre-eclampsia, was found in all hypertensive women, but it was more pronounced in the 28 pre-eclamptic women than in the 8 women with nonproteinuric hypertension. A similar change, however, was seen in 11 of the 18 controls. One serious adverse event occurred, retroperitoneal hematoma, in the woman with the most severe pre-eclampsia.


Glomerular endotheliosis is not to be considered pathognomonic for pre-eclampsia. Few complications followed renal biopsy in this study, but complications arose in the sickest patient. It is probably not advisable to perform antepartum renal biopsies in pregnant women with a rapidly deteriorating renal function and swollen kidneys. In these women, the biopsy does not facilitate diagnosis and is hazardous.

[PubMed - indexed for MEDLINE]
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