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    FEBS Lett. 2007 Jul 10;581(17):3230-4. Epub 2007 Jun 19.

    Biochemical evidence for glucose-independent induction of HXT expression in Saccharomyces cerevisiae.

    Pasula S, Jouandot D 2nd, Kim JH.

    Source

    Mississippi Functional Genomics Network, Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, MS 39406, USA.

    Abstract

    The yeast glucose sensors Rgt2 and Snf3 generate a signal in response to glucose that leads to degradation of Mth1 and Std1, thereby relieving repression of Rgt1-repressed genes such as the glucose transporter genes (HXT). Mth1 and Std1 are degraded via the Yck1/2 kinase-SCF(Grr1)-26S proteasome pathway triggered by the glucose sensors. Here, we show that RGT2-1 promotes ubiquitination and subsequent degradation of Mth1 and Std1 regardless of the presence of glucose. Site-specific mutagenesis reveals that the conserved lysine residues of Mth1 and Std1 might serve as attachment sites for ubiquitin, and that the potential casein kinase (Yck1/2) sites of serine phosphorylation might control their ubiquitination. Finally, we show that active Snf1 protein kinase in high glucose prevents degradation of Mth1 and Std1.

    PMID:
    17586499
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2040036
    Free PMC Article

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