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Clin Pediatr (Phila). 2007 Nov;46(9):831-4. Epub 2007 Jun 21.

Severe hypernatremia and hyperosmolality exacerbated by an herbal preparation in a patient with diabetic ketoacidosis.

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  • 1Division of Pediatric Endocrinology, University of South Alabama Medical Center, Mobile, Alabama 36617-2297, USA.


This article reports a case of severe reversible hypernatremia exacerbated by an herbal agent "goldenseal" (Hydrastis canadensis) in an 11-year-old girl with new onset type I diabetes mellitus presented with diabetic ketoacidosis. A literature review is presented and possible mechanism of hypernatremia caused by this herbal preparation is discussed.

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