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Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10877-81. Epub 2007 Jun 20.

Sir2p-dependent protein segregation gives rise to a superior reactive oxygen species management in the progeny of Saccharomyces cerevisiae.

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  • 1Department of Cell and Molecular Biology-Microbiology, Göteborg University, Medicinaregatan 9C, 413 90 Göteborg, Sweden.

Abstract

Yeast cytokinesis entails a rejuvenation process by which the aged mother cell generates daughter cells enjoying full replicative potential. Here we show that this process includes a precipitous reduction in the levels of reactive oxygen species in the progeny immediately after completion of cytokinesis. The reduction in hydrogen peroxide is the result of a Sir2p and actin cytoskeleton-dependent segregation of the cytosolic catalase Ctt1p such that the daughter cell receives a higher load of undamaged and active Ctt1p than the progenitor cell. Such spatial quality control provides the daughter cells with a superior capacity to combat external oxidative stress and delays self-inflicted oxidative damage to their cellular proteins.

PMID:
17581878
[PubMed - indexed for MEDLINE]
PMCID:
PMC1904135
Free PMC Article
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