Research Tower, Room 629, Department of Biochemistry, UMDNJ-Robert Wood Johnson School of Medicine, 675 Hoes Lane, Piscataway, New Jersey 08854, USA. habasra@umdnj.edu
Non-canonical, beta-catenin-independent Wnt signaling regulates cell polarization and movements. A recent study reveals that casein kinase Iepsilon mediates an additional novel non-canonical Wnt pathway via the activation of the Rap1 GTPase during vertebrate gastrulation.