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Clin Infect Dis. 2007 Jul 15;45(2):263-6. Epub 2007 Jun 6.

Efavirenz to nevirapine switch in HIV-1-infected patients with dyslipidemia: a randomized, controlled study.

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  • 1Epidemiologie, Systemes d'Informations, Modelisation, Institut National de la Sante et de la Recherche Medicale U707, Paris, France.


Many antiretroviral therapies, including efavirenz, are associated with increased serum concentrations of low-density lipoprotein cholesterol. In a small 52-week randomized study, we found that switching from efavirenz to nevirapine was associated with significantly decreased low-density lipoprotein cholesterol levels, compared with continuation of efavirenz therapy (P<.04). A switch to nevirapine was associated with no severe adverse events.

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