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Acta Paediatr. 2007 Aug;96(8):1122-5. Epub 2007 Jun 18.

Reduced IL-10 production and -receptor expression in neonatal T lymphocytes.

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  • 1Department of Paediatrics, Medical University of Lübeck, Germany. schultz@paedia.ukl.mu-luebeck.de

Abstract

AIM:

To further evaluate the underlying mechanism of a formerly demonstrated immature anti-inflammatory response in neonates (1).

METHODS:

Interleukin (IL)-10 production was measured by enzyme-linked immunosorbent-assay (ELISA) after anti-CD3/anti-CD28 costimulation of neonatal and adult T cells. IL-10 receptor expression on T lymphocytes, B lymphocytes and monocytes were analysed by flow cytometry in neonates and adult controls.

RESULTS:

After anti-CD3/anti-CD28 costimulation, IL-10 production of neonatal T lymphocytes was profoundly reduced (median 247 pg/mL vs. 1062 pg/mL, p < 0.0001). IL-10 receptor expression was diminished on neonatal T lymphocytes compared to adults (3% vs. 39.5% IL-10 receptor positive lymphocytes; p < 0.0001). On neonatal B lymphocytes and monocytes the IL-10 receptor expression was comparable to adult controls.

CONCLUSION:

The strongly reduced IL-10 receptor expression on the main immune regulative T lymphocytes in conjunction with a significantly impaired synthesis of IL-10 may play a crucial role in the formerly demonstrated deficient anti-inflammatory immune response in neonates.

[PubMed - indexed for MEDLINE]
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