Contact allergy to acrylates/methacrylates in the acrylate and nail acrylics series in southern Sweden: simultaneous positive patch test reaction patterns and possible screening allergens

Contact Dermatitis. 2007 Jul;57(1):21-7. doi: 10.1111/j.1600-0536.2007.01151.x.

Abstract

In a recent study we showed that all our dental personnel/patients were detected with 2-hydroxyethyl methacrylate (2-HEMA) and 2,2-bis[4-(2-hydroxy-3-methacryloxypropoxy)phenyl]propane (bis-GMA). We studied 90 patients tested to the acrylate and nail acrylics series at our department over a 10 year period to see whether screening allergens could be found. Patch testing with an acrylate and nail acrylics series was performed. Among the 10 acrylate/methacrylate-allergic occupational dermatitis patients tested to the acrylate series, the most common allergens were triethyleneglycol diacrylate (TREGDA, 8), diethyleneglycol diacrylate (5), and 1,4-butanediol diacrylate (BUDA, 5). All 10 of these patients would have been picked up by a short screening series combining TREGDA, 2-hydroxypropyl methacrylate (2-HPMA), and BUDA or 1,6-hexanediol diacrylate (HDDA). Among the 14 acrylate/methacrylate-allergic nail patients, the most common allergens were ethylene glycol dimethacrylate (EGDMA, 11), 2-HEMA, (9), and triethyleneglycol dimethacrylate (9). Screening for 3 allergens i.e. 2-HEMA plus EGDMA plus TREGDA, would have detected all 14 nail patients. A short screening series combining 2-HEMA, EGDMA, TREGDA, 2-HPMA, bis-GMA, and BUDA or HDDA would have picked up all our past study patients (dental, industrial, and nail) with suspected allergy to acrylate/methacrylate allergens.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylates / adverse effects*
  • Acrylates / chemistry
  • Adult
  • Allergens / adverse effects*
  • Dermatitis, Allergic Contact / diagnosis
  • Dermatitis, Allergic Contact / etiology*
  • Dermatitis, Occupational / diagnosis
  • Dermatitis, Occupational / etiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Molecular Structure
  • Occupational Exposure / adverse effects*
  • Patch Tests
  • Retrospective Studies
  • Skin / pathology
  • Sweden

Substances

  • Acrylates
  • Allergens