Antiviral and anti-inflammatory effects of rosmarinic acid in an experimental murine model of Japanese encephalitis

Antimicrob Agents Chemother. 2007 Sep;51(9):3367-70. doi: 10.1128/AAC.00041-07. Epub 2007 Jun 18.

Abstract

Rosmarinic acid (RA) reduced the mortality of mice infected with Japanese encephalitis virus (JEV). Significant decreases in viral loads (P < 0.001) and proinflammatory cytokine levels (P < 0.001) were observed in JEV-infected animals treated with RA compared to levels in infected mice without treatment, at 8 to 9 days postinfection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal*
  • Antiviral Agents*
  • Blotting, Western
  • Chemokines / metabolism
  • Cinnamates / pharmacology*
  • Cytokines / metabolism
  • Depsides / pharmacology*
  • Encephalitis Virus, Japanese / drug effects
  • Encephalitis, Japanese / drug therapy*
  • Encephalitis, Japanese / pathology
  • Encephalitis, Japanese / virology*
  • Mice
  • Rosmarinic Acid

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antiviral Agents
  • Chemokines
  • Cinnamates
  • Cytokines
  • Depsides