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Chem Soc Rev. 2007 Jul;36(7):1173-93. Epub 2007 Mar 5.

Direct transition metal-catalyzed functionalization of heteroaromatic compounds.

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  • 1Department of Chemistry, University of Illinois at Chicago, 845 West Taylor St., Chicago, Illinois 60607-7061, USA.


During the last two decades there has been considerable growth in the development of catalytic reactions capable of activating unreactive C-H bonds. These methods allow for the synthesis of complex molecules from easily available and cheaper precursors in a fewer number of steps. Naturally, the development of C-H activation methods for direct functionalization of heterocyclic molecules, invaluable building blocks for pharmaceutical and synthetic chemistry and material science, has received substantial attention as well. This critical review summarizes the progress made in this field until November 2006 (117 references).

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