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Semin Cell Dev Biol. 2007 Aug;18(4):492-501. Epub 2007 May 6.

The evolution of neurosecretory centers in bilaterian forebrains: insights from protostomes.

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  • 1European Molecular Biology Laboratory, Dev. Biol. Unit, Meyerhofstr. 1, D-69012 Heidelberg, Germany.


Forebrain neurosecretory systems are widespread in the animal kingdom. This review focuses on recent molecular data from protostomes, discusses the original complexity of the bilaterian forebrain neurosecretory system, provides an evolutionary scenario for the emergence of the vertebrate preoptic area/hypothalamus/neurohypophysis and suggests a possible function for an ancient set of sensory-neurosecretory cells present in the medial neurosecretory bilaterian forebrain.

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