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J Surg Educ. 2007 May-Jun;64(3):158-61.

Chronic pancreatitis with synchronous and metachronous malignancy: three unusual cases and a literature review.

Author information

  • 1Department of Surgery, Cabrini Medical Center, New York, NY 1003, USA. waynedocny@hotmail.com

Abstract

HYPOTHESIS:

Chronic pancreatitis is a risk factor for pancreatic cancer. The association between these 2 disease processes is not well known. We present 3 unusual cases of pancreatitis associated with pancreatic cancer and review the possible mechanisms that can cause pancreatitis to degenerate into pancreatic cancer.

DESIGN:

A case series reviewing 3 unusual cases of chronic pancreatitis associated with pancreatic cancer. The patients' charts are reviewed, and a literature search is performed looking for chronic pancreatitis associated with pancreatic cancer.

SETTING:

The cases were performed at a small community hospital in New York City, New York.

PARTICIPANTS:

The surgeons involved are experienced pancreatic surgeons with a large referral group. The endoscopies were performed by gastroenterologists with years of experience in biliary and pancreatic disease.

RESULTS:

The cases and the literature review support the hypothesis that there is an association between chronic pancreatitis and pancreatic cancer.

CONCLUSIONS:

Three unusual case of chronic pancreatitis, 2 with synchronous and 1 with metachronous malignancies, are presented. The pathway of benign to malignant change is reviewed, and the constant awareness that pancreatitis is associated with malignancy must be kept in mind.

PMID:
17574177
[PubMed - indexed for MEDLINE]
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