Cell. 2007 Jun 15;129(6):1041-3.

Taking vesicular transport to the cilium.

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Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada. leroux@sfu.ca

Abstract

Defects in protein trafficking within the cell body and cilia are thought to underlie the human disease Bardet-Biedl syndrome (BBS). In this issue, Nachury et al. (2007) reveal that a large complex of proteins implicated in BBS cooperates with Rabin8-the GTP exchange factor for the small GTPase Rab8-to promote cilia formation and presumably movement of membrane proteins from the cell into the cilium.

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Cell. 2007 Jun 15;129(6):1201-13.

PMID:: 17574016; [PubMed - indexed for MEDLINE]

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A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. [Cell. 2007]
A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.
Nachury MV, Loktev AV, Zhang Q, Westlake CJ, Peränen J, Merdes A, Slusarski DC, Scheller RH, Bazan JF, Sheffield VC, et al. Cell. 2007 Jun 15; 129(6):1201-13.
Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome. [Proc Natl Acad Sci U S A. 2011]
Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome.
Westlake CJ, Baye LM, Nachury MV, Wright KJ, Ervin KE, Phu L, Chalouni C, Beck JS, Kirkpatrick DS, Slusarski DC, et al. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2759-64. Epub 2011 Jan 27.
Differential role of Rab proteins in ciliary trafficking: Rab23 regulates smoothened levels. [J Cell Sci. 2010]
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Boehlke C, Bashkurov M, Buescher A, Krick T, John AK, Nitschke R, Walz G, Kuehn EW. J Cell Sci. 2010 May 1; 123(Pt 9):1460-7. Epub 2010 Apr 7.
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Review Bardet-Biedl syndrome: beyond the cilium. [Pediatr Nephrol. 2007]
Review Bardet-Biedl syndrome: beyond the cilium.
Tobin JL, Beales PL. Pediatr Nephrol. 2007 Jul; 22(7):926-36. Epub 2007 Mar 15.

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Cited by 7 PubMed Central articles

Linking specification to differentiation: from proneural genes to the regulation of ciliogenesis. [Fly (Austin). 2011]
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Zur Lage PI, Simpson TI, Jarman A. Fly (Austin). 2011 Oct 1; 5(4). Epub 2011 Oct 1.
A novel zf-MYND protein, CHB-3, mediates guanylyl cyclase localization to sensory cilia and controls body size of Caenorhabditis elegans. [PLoS Genet. 2010]
A novel zf-MYND protein, CHB-3, mediates guanylyl cyclase localization to sensory cilia and controls body size of Caenorhabditis elegans.
Fujiwara M, Teramoto T, Ishihara T, Ohshima Y, McIntire SL. PLoS Genet. 2010 Nov 24; 6(11):e1001211. Epub 2010 Nov 24.
Deciphering the structure and function of Als2cr4 in the mouse retina. [Invest Ophthalmol Vis Sci. 2010]
Deciphering the structure and function of Als2cr4 in the mouse retina.
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