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1: Arch Soc Esp Oftalmol. 2007 Jun;82(6):377-80.Click here to read Links

[Response to idebenone and multivitamin therapy in Leber's hereditary optic neuropathy]

[Article in Spanish]

Barnils N, Mesa E, Muñoz S, Ferrer-Artola A, Arruga J.

Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España. noebg76@hotmail.com

OBJECTIVE: To ascertain the efficacy of idebenone and multivitamin treatment in Leber's hereditary optic neuropathy (LHON). METHOD: Two patients diagnosed of unilateral LHON were treated with megadoses of idebenone, vitamin C and riboflavin for one year. They were examined clinically before, during and after treatment. RESULTS: No improvement of visual function was observed. Despite the idebenone treatment, in both cases the second eye became involved. CONCLUSIONS: Despite previous reports of visual recovery with idebenone in patients with LHON, our experience shows that an effective treatment for Leber's disease remains to be found.

PMID: 17573650 [PubMed - indexed for MEDLINE]

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