J Neuroimmunol. 2007 Aug;188(1-2):39-47. Epub 2007 Jun 18.

Intraperitoneal inoculation of Sandhoff mouse neonates with an HIV-1 based lentiviral vector exacerbates the attendant neuroinflammation and disease phenotype.

Kyrkanides S, Miller JN, Tallents RH, Brouxhon SM, Centola GM, Olschowka JA.

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Eastman Dental Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States. stephanos_kyrkanides@urmc.rochester.edu <stephanos_kyrkanides@urmc.rochester.edu>

Abstract

We aimed to evaluate the efficacy of VSV-G pseudotyped, defective HIV-1 based lentiviral vectors for the neonatal transfer of therapeutic genes following systemic administration in Sandhoff mouse pups. Despite transgene expression in mouse brains, these animals presented with significant exacerbation and acceleration of the disease neurological phenotype. We observed an increase and acceleration in the presence of MHC-II and CD45+ cells in their brains, along with neuroinflammation, but not in control heterozygous or wild type littermates that also received the same treatment.

PMID:: 17572511; [PubMed - indexed for MEDLINE]

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Intraperitoneal inoculation of Sandhoff mouse neonates with an HIV-1 based lentiviral vector exacerbates the attendant neuroinflammation and disease phenotype.

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