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Biochim Biophys Acta. 2007 Jun;1775(2):237-62. Epub 2007 Jun 6.

Chemotherapy-induced resistance by ATP-binding cassette transporter genes.

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  • 1Department of Biology, University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium. gilletjp@mail.nih.gov

Abstract

A key issue in the treatment of many cancers is the development of resistance to chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them is mediated by the overexpression of ATP-binding cassette (ABC) transporters able to efflux drugs out of the tumor cell. The last two decades have seen notable growth of knowledge concerning the involvement of ABC transporters in resistance to chemotherapy. This review emphasizes these transporters, their clinical relevance and the diagnostic methods and strategies to circumvent multidrug resistance (MDR) mediated by ABC transporters.

PMID:
17572300
[PubMed - indexed for MEDLINE]
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