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Neuroradiology. 2007 Sep;49(9):761-6. Epub 2007 Jun 14.

Safety of endovascular treatment of intracranial aneurysms with a new, complex shaped Guglielmi detachable coil.

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  • 1Department of Neuroradiology, Hôpital Roger Salengro, University Hospital Lille, Lille, France.



The Guglielmi detachable coil (GDC) 360 degrees, a new complex shaped bare platinum coil, became available in Europe for aneurysm treatment in September 2005. The purpose of this study was to assess the feasibility and safety of selective embolization of intracranial aneurysms with the GDC 360 degrees in 52 consecutive patients.


All patients included in this study were registered in a prospectively maintained database. We assessed the patient clinical history, aneurysm shape and dimensions, technical details and complications of the procedures, degree of aneurysm occlusion, and clinical findings upon discharge. In all patients, the first coil deployed was a GDC 360 degrees .


Over a 6-month period, we intended to treat 52 aneurysms with the GDC 360 degrees in 52 patients. Of these 52 patients, 42 (81%) were treated in the context of subarachnoid haemorrhage. In 51 of 52 patients, the underlying aneurysm was successfully treated by coil embolization. Six procedures (11.5%) were complicated by the formation of thrombus in the parent artery during the intervention. One patient suffered a stroke related to the procedure. Angiograms obtained immediately after the procedure showed complete occlusion of the aneurysmal sac in 38 of 51 procedures (74.5%), a neck remnant in 11 (21.6%), and a residual aneurysm in 2 (3.9%). In 43 of 51 patients (84.3%), clinical assessment demonstrated independent clinical status, whereas 7 patients (13.7%) required assistance in the activities of daily living upon hospital discharge. One patient (2.0%) died after development of a severe vasospasm 10 days after the endovascular procedure.


The GDC 360 degrees can be safely used for the endovascular occlusion of intracranial aneurysms.

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