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J Biochem. 2007 Jul;142(1):11-5. Epub 2007 Jun 13.

Cross-talks between transcription and post-transcriptional events within a 'mRNA factory'.

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  • 1Department of Functional Genomics, Medical Research Institute; Laboratory of Gene Expression, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 113-8510, Japan. m.hagiwara.end@mri.tmd.ac.jp


Eukaryotic gene expression is controlled in multi steps. Pre-messenger RNAs (pre-mRNAs) transcribed by RNA polymerase II (RNAPII) are capped at 5' end, spliced to remove introns and polyadenylated at 3' end. These processes are followed by other post-transcriptional steps that include mRNA export, translation and mRNA degradation. Recent studies have shown that individual events occurring during eukaryotic gene expression are coupled together under more elaborate regulatory controls. In this review, the molecular and functional cross-talks between transcription and the post-transcriptional events are overviewed.

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