Nutr Rev. 2007 May;65(5):181-217.

Update: effects of antioxidant and non-antioxidant vitamin supplementation on immune function.

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Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave., Boston, MA, 02115, USA. awebb@hsph.harvard.edu

Abstract

The purpose of this manuscript is to review the impact of supplementation with vitamins E and C, carotenoids, and the B vitamins on parameters of innate and adaptive immune function as reported from clinical trials in humans. There is evidence to support causal effects of supplementation with vitamins E and C and the carotenoids singly and in combination on selected aspects of immunity, including the functional capacity of innate immune cells, lymphocyte proliferation, and the delayed-type hypersensitivity (DTH) response. Controlled intervention trials of B vitamin-containing multivitamin supplements suggest beneficial effects on immune parameters and clinical outcomes in HIV-positive individuals.

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Update: effects of antioxidant and non-antioxidant vitamin supplementation on immune function.

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