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    Int J Obes (Lond). 2007 Nov;31(11):1756-9. Epub 2007 Jun 12.

    Weight loss during chronic, cervical vagus nerve stimulation in depressed patients with obesity: an observation.

    Pardo JV, Sheikh SA, Kuskowski MA, Surerus-Johnson C, Hagen MC, Lee JT, Rittberg BR, Adson DE.

    Source

    Cognitive Neuroimaging Unit (11P), Psychiatry Service, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA. jvpardo@umn.edu

    Abstract

    Fourteen patients were treated over 2 years with cervical vagus nerve stimulation (VNS) for adjunctive therapy of severe, treatment-resistant depression. Here, we report the serendipitous observation that this treatment was associated with highly significant, gradual weight loss despite the patients' report of not dieting or exercising. The weight loss was proportional to the initial BMI, that is, the more severe the obesity, the greater the weight loss. Weight loss did not correlate with changes in mood symptoms. The vagus nerve carries visceral information to and from the brain; modulation of its activity may alter eating behavior. Chronic cervical VNS may merit controlled study for the treatment of severe obesity.

    PMID:
    17563762
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2365729
    Free PMC Article

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