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Nihon Rinsho. 2007 Jun;65(6):1029-33.

[Identification and application of marker genes for differential diagnosis of chronic fatigue syndrome].

[Article in Japanese]

Author information

  • 1Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School.


Chronic fatigue syndrome (CFS) is a complex disease and has no laboratory biomarkers, which makes diagnosis of CFS difficult. Several research groups challenged to identify genes specific for CFS; however, there are no overlaps between studies. The U.S. Centers for Disease Control and Prevention reported remarkable gene expression profiles of a large scale cohort study recruited 227 people. Reported genes were mostly different from the previously reported genes, again featuring the complexity of CFS. Separately, we identified 9 genes that were significantly and differentially expressed between CFS patients and healthy subjects using an original microarray. The changes in expression of 9 genes were confirmed by quantitative PCR. We also demonstrated the usefulness of 9 genes for differential diagnosis of CFS.

[PubMed - indexed for MEDLINE]
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