Mol Cell. 2007 Jun 8;26(5):611-23.

Argonaute proteins: mediators of RNA silencing.

Source

Laboratory of RNA Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.

Abstract

Small regulatory RNAs such as short interfering RNAs (siRNAs), microRNAs (miRNAs), and Piwi interacting RNAs (piRNAs) have been discovered in the past, and it is becoming more and more apparent that these small molecules have key regulatory functions. Small RNAs are found in all higher eukaryotes and play important roles in cellular processes as diverse as development, stress response, or transposon silencing. Soon after the discovery of small regulatory RNAs, members of the Argonaute protein family were identified as their major cellular protein interactors. This review focuses on the various cellular functions of mammalian Argonaute proteins in conjunction with the different small RNA species that are known today.

PMID:: 17560368; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Supplemental Content

Related citations

Review The Argonaute protein family. [Genome Biol. 2008]
Review The Argonaute protein family.
Höck J, Meister G. Genome Biol. 2008; 9(2):210. Epub 2008 Feb 26.
Review The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members. [Development. 2008]
Review The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members.
Farazi TA, Juranek SA, Tuschl T. Development. 2008 Apr; 135(7):1201-14. Epub 2008 Feb 20.
A C. elegans Piwi, PRG-1, regulates 21U-RNAs during spermatogenesis. [Curr Biol. 2008]
A C. elegans Piwi, PRG-1, regulates 21U-RNAs during spermatogenesis.
Wang G, Reinke V. Curr Biol. 2008 Jun 24; 18(12):861-7. Epub 2008 May 22.
Review [A novel class of testis-specific small RNAs: piRNAs]. [Zhonghua Nan Ke Xue. 2008]
Review [A novel class of testis-specific small RNAs: piRNAs].
Ding XF, Li HG, Xiong CL. Zhonghua Nan Ke Xue. 2008 Feb; 14(2):163-5.
Review Small RNAs just got bigger: Piwi-interacting RNAs (piRNAs) in mammalian testes. [Genes Dev. 2006]
Review Small RNAs just got bigger: Piwi-interacting RNAs (piRNAs) in mammalian testes.
Kim VN. Genes Dev. 2006 Aug 1; 20(15):1993-7.

See reviews... See all...

Cited by 89 PubMed Central articles

Transcriptional gene silencing of HIV-1 through promoter targeted RNA is highly specific. [RNA Biol. 2011]
Transcriptional gene silencing of HIV-1 through promoter targeted RNA is highly specific.
Suzuki K, Ishida T, Yamagishi M, Ahlenstiel C, Swaminathan S, Marks K, Murray D, McCartney EM, Beard MR, Alexander M, et al. RNA Biol. 2011 Nov-Dec; 8(6):1035-46. Epub 2011 Nov 1.
Synthetic Pre-miRNA-Based shRNA as Potent RNAi Triggers. [J Nucleic Acids. 2011]
Synthetic Pre-miRNA-Based shRNA as Potent RNAi Triggers.
Terasawa K, Shimizu K, Tsujimoto G. J Nucleic Acids. 2011; 2011:131579. Epub 2011 Jul 12.
miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA components. [Nucleic Acids Res. 2011]
miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA components.
Roberts AP, Lewis AP, Jopling CL. Nucleic Acids Res. 2011 Sep 1; 39(17):7716-29. Epub 2011 Jun 7.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Argonaute proteins: mediators of RNA silencing.
Argonaute proteins: mediators of RNA silencing.
Mol Cell. 2007 Jun 8 ;26(5):611-23.

PubMed
Ingestion of diet soda before a glucose load augments glucagon-like peptide-1 se...
Ingestion of diet soda before a glucose load augments glucagon-like peptide-1 secretion.
Diabetes Care. 2009 Dec ;32(12):2184-6. Epub 2009 Oct 6 .

PubMed
Psychopharmacology of borderline personality disorder.
Psychopharmacology of borderline personality disorder.
Psychiatr Clin North Am. 2000 Mar ;23(1):169-92, ix.

PubMed
Clematis vitalba L. aerial part exhibits potent anti-inflammatory, antinocicepti...
Clematis vitalba L. aerial part exhibits potent anti-inflammatory, antinociceptive and antipyretic effects.
J Ethnopharmacol. 2007 Apr 4 ;110(3):504-15. Epub 2006 Oct 20 .

PubMed
Correcting for purifying selection: an improved human mitochondrial molecular cl...
Correcting for purifying selection: an improved human mitochondrial molecular clock.
Am J Hum Genet. 2009 Jun ;84(6):740-59. Epub 2009 Jun 4 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Argonaute proteins: mediators of RNA silencing.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Supplemental Content

Related citations

Cited by 89 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information