Rev Med Interne. 2007 Oct;28(10):677-81. Epub 2007 May 25.

[Genetic abnormalities in multiple myeloma: role in oncogenesis and impact on survival].

[Article in French]

Decaux O, Lodé L, Minvielle S, Avet-Loiseau H.

Source

Service de médecine interne, hôpital Sud, 16 boulevard de Bulgarie, BP 90347, 35203 Rennes cedex 02, France. olivier.decaux@chu-rennes.fr

Abstract

PURPOSE:

Recent development of interphase fluorescence in situ hybridization (FISH) allows analysis on non-proliferant plasma cells. We describe the most frequent genetic abnormalities in multiple myeloma and their prognostic value. CURRENT KNOWLEDGE AND

KEY POINTS:

Most frequent genetic abnormalities are illegitimate rearrangements involving the IGH gene at 14q32 (60% of patients), hyperdiploidy (50 to 60% of patients), chromosome 13 deletion (40 to -50% of patients), chromosome 1q gain (30 to -40% of patients) chromosome 17 deletion (10% of patients). Some of these genetics abnormalities are observed in monoclonal gammopathy of undetermined significance (MGUS), a pre-malignant state. t(4;14) and t(14;16) translocations and chromosome 17 deletion negatively impact the overall survival. Patients with these genomic aberrations should be treated with specific treatment.

FUTURE PROSPECTS AND PROJECTS:

Identification of genetic abnormalities is important for evaluation of prognosis and treatment protocol in multiple myeloma.

PMID:: 17559979; [PubMed - indexed for MEDLINE]

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