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Immunol Today. 1991 Sep;12(9):338-42.

The response of human platelets to activated components of the complement system.

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  • 1Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104.


Many in vivo platelet responses are considered to be mediated, directly or indirectly, by activated components of the complement system. These include the secretion of proteolytic enzymes and the assembly of key enzymes of the coagulation and fibrinolytic pathways. In this review, Peter J. Sims and Therese Wiedmer summarize the known interactions of human platelets with the complement system and discuss the implications of these interactions for platelet hemostatic function within the vasculature.

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