J Proteome Res. 2007 Jul;6(7):2550-64. Epub 2007 Jun 9.

Comparative proteomic expression profile in all-trans retinoic acid differentiated neuroblastoma cell line.

Cimmino F, Spano D, Capasso M, Zambrano N, Russo R, Zollo M, Iolascon A.

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Dipartimento di Biochimica e Biotecnologie Mediche, Universita'di Napoli Federico II, Centro di Ingegneria Genetica CEINGE- Biotecnologie Avanzate, Napoli, Italy.

Abstract

Neuroblastoma (NB) is an infant tumor which frequently differentiates into neurons. We used two-dimensional differential in-gel electrophoresis (2D-DIGE) to analyze the cytosolic and nuclear protein expression patterns of LAN-5 cells following neuronal differentiating agent all-trans-retinoic acid treatment. We identified several candidate proteins, from which G beta2 and Prefoldin 3 may have a role on NB development. These results strength the use of proteomics to discover new putative protein targets in cancer.

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Comparative proteomic expression profile in all-trans retinoic acid differentiat...
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