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Nat Genet. 2007 Jul;39(7):827-9. Epub 2007 Jun 10.

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.

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  • 1Centre for Gastroenterology, Institute of Cell and Molecular Science, Queen Mary University of London, London E1 2AT, UK. d.vanheel@qmul.ac.uk

Abstract

We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease.

PMID:
17558408
[PubMed - indexed for MEDLINE]
PMCID:
PMC2274985
Free PMC Article

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