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J Clin Oncol. 2007 Jun 10;25(17):2345-51.

Greater survival after breast cancer in physically active women with high vegetable-fruit intake regardless of obesity.

Author information

  • 1Cancer Prevention and Control Program, Moores University of California, San Diego Cancer Center, La Jolla, CA 92093-0901, USA. jppierce@ucsd.edu

Abstract

PURPOSE:

Single-variable analyses have associated physical activity, diet, and obesity with survival after breast cancer. This report investigates interactions among these variables.

PATIENTS AND METHODS:

A prospective study was performed of 1,490 women diagnosed and treated for early-stage breast cancer between 1991 and 2000. Enrollment was an average of 2 years postdiagnosis. Only seven women were lost to follow-up through December 2005.

RESULTS:

In univariate analysis, reduced mortality was weakly associated with higher vegetable-fruit consumption, increased physical activity, and a body mass index that was neither low weight nor obese. In a multivariate Cox model, only the combination of consuming five or more daily servings of vegetables-fruits, and accumulating 540+ metabolic equivalent tasks-min/wk (equivalent to walking 30 minutes 6 d/wk), was associated with a significant survival advantage (hazard ratio, 0.56; 95% CI, 0.31 to 0.98). The approximate 50% reduction in risk associated with these healthy lifestyle behaviors was observed in both obese and nonobese women, although fewer obese women were physically active with a healthy dietary pattern (16% v 30%). Among those who adhered to this healthy lifestyle, there was no apparent effect of obesity on survival. The effect was stronger in women who had hormone receptor-positive cancers.

CONCLUSION:

A minority of breast cancer survivors follow a healthy lifestyle that includes both recommended intakes of vegetables-fruits and moderate levels of physical activity. The strong protective effect observed suggests a need for additional investigation of the effect of the combined influence of diet and physical activity on breast cancer survival.

Comment in

PMID:
17557947
[PubMed - indexed for MEDLINE]
PMCID:
PMC2274898
Free PMC Article

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