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    Science. 2007 Jun 29;316(5833):1908-12. Epub 2007 Jun 7.

    Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery.

    Carlton JG, Martin-Serrano J.

    Source

    Department of Infectious Diseases, King's College London School of Medicine, London, UK.

    Abstract

    During cytokinesis, as dividing animal cells pull apart into two daughter cells, the final stage, termed abscission, requires breakage of the midbody, a thin membranous stalk connecting the daughter cells. This membrane fission event topologically resembles the budding of viruses, such as HIV-1, from infected cells. We found that two proteins involved in HIV-1 budding-tumor susceptibility gene 101 (Tsg101), a subunit of the endosomal sorting complex required for transport I (ESCRT-I), and Alix, an ESCRT-associated protein-were recruited to the midbody during cytokinesis by interaction with centrosome protein 55 (Cep55), a centrosome and midbody protein essential for abscission. Tsg101, Alix, and possibly other components of ESCRT-I were required for the completion of cytokinesis. Thus, HIV-1 budding and cytokinesis use a similar subset of cellular components to carry out topologically similar membrane fission events.

    PMID:
    17556548
    [PubMed - indexed for MEDLINE]

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