Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Development. 2007 Jul;134(14):2569-77. Epub 2007 Jun 6.

Ftm is a novel basal body protein of cilia involved in Shh signalling.

Author information

  • 1Institut für Entwicklungs- und Molekularbiologie der Tiere EMT, Heinrich-Heine-Universität, 40225 Düsseldorf, Germany.

Abstract

In this study we show in mice that Ftm (Rpgrip1l) is located at the ciliary basal body. Our data reveal that Ftm is necessary for developmental processes such as the establishment of left-right asymmetry and patterning of the neural tube and the limbs. The loss of Ftm affects the ratio of Gli3 activator to Gli3 repressor, suggesting an involvement of Ftm in Shh signalling. As Ftm is not essential for cilia assembly but for full Shh response, Ftm can be considered as a novel component for cilium-related Hh signalling. Furthermore, the absence of Ftm in arthropods underlines the divergence between vertebrate and Drosophila Hh pathways.

PMID:
17553904
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire
    Loading ...
    Write to the Help Desk