Bioorg Med Chem Lett. 2007 Aug 1;17(15):4343-6. Epub 2007 May 13.

Antimicrobial activity of rationally designed amino terminal modified peptides.

Bisht GS, Rawat DS, Kumar A, Kumar R, Pasha S.

Source

Peptide Research Laboratory, Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India.

Abstract

Series of short amino terminal modified cationic peptides were designed and synthesized. All of the synthesized compounds were tested against gram-positive as well as gram-negative bacterial strain. Some of the compounds exhibit potent antibacterial activity and no hemolytic activity even at high dose level (1000 microg/mL) in mammalian erythrocytes was observed.

PMID:: 17553680; [PubMed - indexed for MEDLINE]

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