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J Am Acad Dermatol. 2007 Aug;57(2):301-14. Epub 2007 Jun 5.

Contact dermatitis of the hands: cross-sectional analyses of North American Contact Dermatitis Group Data, 1994-2004.

Author information

  • 1Department of Dermatology, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA. erin.warshaw@med.va.gov

Abstract

BACKGROUND:

Hand dermatitis, including irritant and allergic contact dermatitis (ACD), is common.

OBJECTIVE:

To evaluate allergens, relevant irritants, sources and occupations associated with hand contact dermatitis using North American Contact Dermatitis Group (NACDG) data.

METHODS:

A cross-sectional analysis of 22,025 patients patch tested between 1994 and 2004.

RESULTS:

Hand involvement was found in 6953 patients; 959 had ACD as the only diagnosis. In these 959 patients, the 12 most frequent relevant allergens were quaternium-15 (16.5%), formaldehyde (13.0%), nickel sulfate (12.2%), fragrance mix (11.3%), thiuram mix (10.2%), balsam of Peru (9.6%), carba mix (7.8%), neomycin sulfate (7.7%), bacitracin (7.4%), methyldibromoglutaronitrile/phenoxyethanol 2.0% (7.4%), cobalt chloride (6.5%), and methyldibromoglutaronitrile/phenoxyethanol 2.5% (6.3%). Rubber allergens were most commonly associated with occupation. One third of patients with hand ACD had identifiable relevant irritants.

LIMITATIONS:

Cross-sectional analyses prevent evaluation of causal associations.

CONCLUSION:

In NACDG patients with hand ACD, the most common allergens included preservatives, metals, fragrances, topical antibiotics, and rubber additives.

PMID:
17553593
[PubMed - indexed for MEDLINE]
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