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Emerg Infect Dis. 2007 Mar;13(3):380-7.

Worldwide emergence of extensively drug-resistant tuberculosis.

Author information

  • 1Centers for Disease Control and Prevention, Atlanta, Georgia, USA. sshah@montefiore.org

Abstract

Mycobacterium tuberculosis strains that are resistant to an increasing number of second-line drugs used to treat multidrug-resistant tuberculosis (MDR TB) are becoming a threat to public health worldwide. We surveyed the Network of Supranational Reference Laboratories for M. tuberculosis isolates that were resistant to second-line anti-TB drugs during 2000-2004. We defined extensively drug-resistant TB (XDR TB) as MDR TB with further resistance to > or = 3 of the 6 classes of second-line drugs. Of 23 eligible laboratories, 14 (61%) contributed data on 17,690 isolates, which reflected drug susceptibility results from 48 countries. Of 3,520 (19.9%) MDR TB isolates, 347 (9.9%) met criteria for XDR TB. Further investigation of population-based trends and expanded efforts to prevent drug resistance and effectively treat patients with MDR TB are crucial for protection of public health and control of TB.

PMID:
17552090
[PubMed - indexed for MEDLINE]
PMCID:
PMC2725916
Free PMC Article
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