Cell Metab. 2007 Jun;5(6):405-7.

FGF21: a missing link in the biology of fasting.

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Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ 07065, USA. marc_reitman@merck.com

Abstract

A sufficient energy supply is essential for life; consequently, multiple mechanisms have evolved to ensure both energy availability and conservation during fasting and starvation. Two reports in this issue of Cell Metabolism (Badman et al., 2007; Inagaki et al., 2007) demonstrate that FGF21, a circulating protein produced in the liver in response to the PPARalpha transcription factor, is a "missing link" in the biology of fasting, inducing adipose tissue lipolysis, liver ketogenesis, and metabolic adaptation to the fasting state.

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Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. [Cell Metab. 2007]
Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states.Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E. Cell Metab. 2007 Jun; 5(6):426-37.
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. [Cell Metab. 2007]
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21.Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, et al. Cell Metab. 2007 Jun; 5(6):415-25.

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Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. [Cell Metab. 2007]
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Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, et al. Cell Metab. 2007 Jun; 5(6):415-25.
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