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Am J Obstet Gynecol. 2007 Jun;196(6):544.e1-5.

Increasing use of antidepressants in pregnancy.

Author information

  • 1Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232-2504, USA. william.cooper@vanderbilt.edu

Abstract

OBJECTIVE:

The purpose of this study was to quantify the rate of exposures to antidepressants during pregnancy in a large cohort of women.

STUDY DESIGN:

This was a retrospective cohort study of 105,335 pregnancies among women enrolled in Tennessee Medicaid from 1999-2003. Pregnancies were classified according to antidepressant exposures during pregnancy using previously validated computerized pharmacy records linked with birth certificates.

RESULTS:

During the study period, 8.7% of women giving birth had exposure to any antidepressant; 6.2% had exposure to a selective serotonin reuptake inhibitor. Maternal age > 25 years (P < .0001), white race (P < .0001), and education > 12 years (P = .008) were significant predictors of antidepressant exposure. The proportion of pregnancies with antidepressant use increased from 5.7% of pregnancies in 1999 to 13.4% of pregnancies in 2003 (p < .0001). The increase was mostly accounted for by increases in selective serotonin reuptake inhibitor exposures.

CONCLUSION:

There is an urgent need for further studies that better quantify the fetal consequences of exposure to antidepressants.

PMID:
17547888
[PubMed - indexed for MEDLINE]
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